POINTWISE MUTUAL INFORMATION QUANTIFIES INTRATUMOR HETEROGENEITY IN TISSUE SECTIONS LABELED WITH MULTIPLE FLUORESCENT BIOMARKERS

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships Food among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to qua

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Establishing a Uniform Practice through Interpretation of International Convention on Carriage of Goods by Sea

Rotterdam Rules by expanding the jurisdiction and arbitration scope, took an important step towards the unified application of international rules governing the Carriage of Goods by Sea.At the same time, the extended scope of competent First Aid Kits authority in this Convention to hear a case by different and numerous authorities would bring diver

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